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Cancer-associated fibroblast-secreted exosomal miR-454-3p inhibits lipid metabolism and ferroptosis in breast cancer by targeting ACSL4

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6 Ribulose 5-phosphate+ H 2 O 5 Glucose 6-phosphate + P i Finally, by summing all three groups of reactions, the oxidative phase, non-oxidative phase, and gluconeogenic steps, the overall reaction is: Glucose 6-phosphate + 12 NADP + + 7 H 2 O 6 CO 2 + 12 NADPH + 12 H + + P i Thus, one molecule of glucose 6-phosphate, through six complete cycles of the pentose phosphate pathway (coupled with specific gluconeogenic reactions), is oxidized to six molecules of CO 2